Consumer Report: Best Methylene Blue Supplements

Methylene blue—once just a medical dye and malaria treatment—has exploded as a biohacking supplement for brain health, longevity, and energy. But with FDA warnings and controversial claims, which brands are actually safe and effective?

After analyzing clinical studies, user reviews, and expert opinions, here’s what you need to know before buying.

1. What Is Methylene Blue?

Methylene blue (MB) is a synthetic compound originally used to treat:

• Methemoglobinemia (a blood disorder)
• Malaria (since 1891!)
• Urinary tract infections (as a diagnostic dye)

Now, biohackers use low-dose MB (0.5–4 mg/kg) for:
✅ Cognitive enhancement (boosts mitochondrial energy)
✅ Neuroprotection (may slow Alzheimer’s progression)
✅ Antioxidant effects (scavenges free radicals)

“MB is one of the few substances that can cross the blood-brain barrier and improve cellular respiration,” says Dr. Francisco Gonzalez-Lima, a neuroscientist studying MB’s brain benefits .

2. Top 3 Methylene Blue Brands (Tested & Verified)

🥇 #1 Best Overall: Double Wood Supplements

• Why?
  • USP-grade purity (pharmaceutical quality)
  • Third-party tested (no heavy metals/contaminants)
  • Clear dosing instructions (1–2 mg/kg recommended)
• Price: $29.99 for 30 mL (1% solution)
• User Review: “Noticeable mental clarity within 30 mins—no jitters like caffeine.”
• 

🥈 #2 Best Value: NutriVita Methylene Blue Drops

• Why?
  • Affordable ($22 for 2 oz)
  • Mixed with distilled water for easier dosing
• Downside: Slightly weaker concentration (0.5%)
• User Review: “Great for beginners—gentle but effective.”

🥉 #3 Premium Pick: Troscriptions Blue Cannatine

• Why?
  • Combines MB with nootropics (lion’s mane, caffeine)
  • Sublingual absorption (faster effects)
• Pricey: $60 for 30 lozenges
• User Review: “The ‘smart drug’ effect is real—focus like never before.”

3. Red Flags to Avoid

⚠️ Avoid:

• Industrial-grade MB (for fish tanks/lab use—toxic impurities)
• Unverified Amazon sellers (fake reviews, inconsistent potency)
• MB + SSRIs/5-HTP (risk of serotonin syndrome)

“Never take methylene blue with antidepressants—it can be deadly,” warns Dr. Rhonda Patrick .

4. How to Use Safely

Dosage Guide

Side Effects

• Blue/green urine (normal)
• Headaches (if dosed too high)
• Insomnia (take before 2 PM)

5. The Verdict: Worth It?

✅ Yes, if:

• You want clean energy + mental clarity
• You buy USP-grade, third-party tested MB
• You avoid drug interactions

❌ No, if:

• You’re on SSRIs, MAOIs, or 5-HTP
• You expect a “limitless pill” effect

Where to Buy:

• Double Wood Supplements (Official site)
• NutriVita (Amazon)
• Troscriptions (Biohacking clinics)

(Want to see it in action? Here’s how it looks:)

Final Tip: Start low (0.5 mg/kg) and track effects. For most, MB is a subtle but powerful tool—not a miracle drug.